ATP‐sensitive potassium channels in capillaries isolated from guinea‐pig heart
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چکیده
منابع مشابه
Inhibition by steroids of the uptake of potassium by capillaries isolated from rat brain.
The effect of steroids on the uptake and release of K+ by capillaries isolated from rat brain was investigated. 86Rb’ uptake was used as a transport analog of K+. The uptake of 86Rb’ by the capillaries was markedly inhibited by ouabain. The ouabain sensitive fraction of 86Rb’ uptake was inhibited by corticosterone with an 150 of 8 X 10m4M. Inhibition was immediate in onset and rapidly reversibl...
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Capillaries were isolated from bovine retina by homogenization and glass bead filtration in order to study their ability to transport certain solutes. Viability of the microvessels was demonstrated by their ability to maintain linear rates of substrate oxidation for more than two hours. He.uose uptake (measured using 3-o-methyl-D-glucose) could be inhibited b3 cytochalasin R, phloretin and phlo...
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Brain capillary endothelial cells form a blood-brain barrier (BBB) that appears to play a role in fluid and ion homeostasis in brain. One important transport system that may be involved in this regulatory function is the Na+, K+-ATPase that was previously demonstrated to be present in isolated brain capillaries. The goal of the present study was to identify additional Na+ transport systems in b...
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The failing heart undergoes a process of pathological electrical remodelling that is characterized by maladaptive alterations in ion channel expression and function. This shift in phenotype manifests as electrical instability which increases the occurrence of arrhythmic sudden death. Indeed, it is estimated that of the 300 000 annual deaths related to heart failure, up to 50% are the result of ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2000
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.2000.t01-1-00307.x